RESEARCH ACTIVITY AT BISR
- DOMAP (Database of Medicinal & Aromatic Plants in Rajasthan)
- CASSP (Comparative Analysis of Secondary Structure of Proteins in Extremophiles)
- PIASP (Protein Interaction Analyzer and Structure Parser)
- CRAT (Codon Restriction Analysis Tool)
- DisProlic (Database of Interaction Specificity in Protein-Ligand Complex)
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Database of Medicinal & Aromatic Plants in Rajasthan
DOMAP contains information about the aromatic and medicinal plants belong to
Aravalli hills in Rajasthan. In the initial version, the number of plants included is 139.
DOMAP was developed using RDBMS Technology. The database is under continuous upgradation,
so user can create their login account and may suggest new plants or any modification.
The strong backend system was implemented which supports stringent plant verification
system involving multiple verifiers.
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Protein Interaction Analyzer & Structure Parser
PIASP is web based tool to mine Structurally Conserved Atomic Interactions in family of complexes.
It gives you the complete interaction profile of receptor-ligand interactions at different angstrom level.
The interface is user friedly and can be customized for different level of atomic distance & structural conservation.
Besides, various utility tools have been developed to study protein-ligand interaction.
A set of tools has been developed to parse various PDB records.
Researcher can perform the interaction mapping of ligand in two biological complexes.
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Codon Restriction Analysis Tool
CRAT is a web based tool for understanding the effect of codon restriction
on molecular evolution. CRAT imposes the criteria of restricted codons while back-tranlation
and evaluates the effect by comparing the phylogenetic tree. The codon restriction is based upon
the codon usage table from four extremophilic groups.
Besides, few utility tools have also been incorporated for related study such as
Phylogenetic tree reconstruction, Comparison of Phylogenetic Trees etc.
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Comparative Analysis of SSEs from Extremophilic Proteins
CASSP is an database driven interface for comparative analysis of secondary structure elements
from selected extremophilic proteins. The current version included 106 structures from four
temperature based groups i.e. thermophiles, hyperthermophiles, mesophiles & psychrophiles.
Other utiities included in CASSP are parsing of SSEs from Protein Structure in PDB format and calculation of amino acid
residual composition given any PDB structure.
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Database of Interaction Study in Protein-Ligand Complex
Disprolic is a web based tool to analyze atomic interaction of ligand to its receptors
in a given Protein-Ligand Complex. At present the tool can analyze the interact of 20 ligand binding
protein complexes. Two methods have been implemented in the tool, first method is connectivity matrix
based and second is on user-defined distance (Euclidian distance/RMSD) based.
Other utiities included in CASSP are parsing of SSEs from Protein Structure in PDB format and calculation of amino acid
residual composition given any PDB structure.
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