Vibrio vulnificus The Gram-negative bacterium,a ubiquitous inhabitant of estuarine waters, and is one of the parior cause of seafood-related deaths therefore highly prevalent in number in shellfish molluscan around the world.Vibrio vulnificus is an halophile ,an etiologic agent responsible to causes gastroenteritis and also responsible to cause human mortalty.V. vulnificus show high degree of genotypic and phenotypic Heterogeneity among them.V. vulnificus are classified into biotypes based on their biochemical characteristics. Strains belonging to biotype 1 are responsible for the majority of human infections, while biotype 2 strains are primarily eel pathogens . A recently identified third biotype (biotype 3) was shown to pos- sess biochemical properties of both biotypes 1 and 2 and to cause human wound infection and other; diarrheal disease, Chronic illness,skin lesions,fever .Hypotension Liver disease Illness . The etiologic is an of human mortality from seafood-borne infection.t is a human pathogen known to cause gastroenteritis, which is an infection of the stomach and intestines, wound infections and primary septicemia, which occurs when the bacterium enters the host's blood and causes infection throughout the body.It can cause serious wound infections with lethal outcome and is also responsible for cases of death caused by consumption of contaminated seafood. In the United States, particularly oysters contaminated with V. vulnificus have been reported to be responsible for deadly infections world. In the 10-year period between 2000 and 2009, 303 cases involving oyster ingestion occurred in the United States, of which 148 were fatal.