Cryptosporidium parvum

Cryptosporidium is a microscopic and apicomplexan parasite.C. parvum is an obligate intracellular parasite, that infects both humans and livestock transmitted via highly durable oocysts in feces.Development inculde both a cyclic asexual reproduction and the production of gametes giving rise to further oocysts, which are either excreted or reinfect the host.C. Parvum oocysts-forming apicomplexan protozoa, which complete their life cycle both in humans and animals, through zoonotic and anthroponotic transmission, causing cryptosporidiosis. Cryptosporidium paravum is most commonly known for waterborne transmissionmore but recently identified as an emerging food contaminant. Several documented food-associated outbreaks have been reported in improperly pasteurized milk , chicken salad in , uncooked green onions.

Organism Details:
Shape and Size
4·5 × 5·5 ¼m
Genome Information
Cryptosporidium parvum is a obligate intracellular and Zoonotic parasitea.Cryptosporidium parvum lowa ( GI:221248419) has a circular DNA chromosome of 9087724 bp. was not been completely sequenced .The genome structure of Cryptosporidium parvum consists of 3,887 genes and 3,805 coding proteins, rRNAs: 15, tRNAs 45. The GC content of Cryptosporidium parvum is about 30.0 %
Food Source
fresh vegetables ,fruits and seafood
Pathological Factor
Cryptosporidium paravum life cycle begins with the ingestion of the sporulated oocysts by the susceptible host; the oocysts undergo excystation and release four infective sporozoite. the parasite establishes itself in a membrane-bound compartment on the apical surface of the intestinal epithelium, it will lead to cause host cell damage. Nevertheless, it causes significant abnormalities in the absorptive and secretory functions of the gut. This damage could be the result of direct injury to the host epithelial cells or could be indirect through the effect of inflammatory cells and cytokines recruited to the site of infection.
Disease
cryptosporidiosis the major cause of Cryptosporidium.Cryptosporidium that cause intestinal diseases in human. The severity of a Cryptosporidium infection can vary from an asymptomatic shedding of oocysts to a severe and life-threatening disease. Immunocompetent individuals experience a transient self-limiting illness (up to 2 to 3 weeks).For immunocompromised patients, cryptosporidiosis can be a critical illness with persistent symptoms leading to dehydration and wasting. C. parvum has emerged as a very important pathogen worldwide due to its morbidity and mortatility in AIDS patient .
Affected Body Organs
Classification
Kingdom Chromalveolata
Phylum Apicomplexa
Class Conoidasida
Subclass Coccidiasina
Order Eucoccidiorida
Family Cryptosporidiidae
Genus Cryptosporidium
Species C. Parvum